Asymmetric total synthesis of smyrindiol employing an organocatalytic aldol key step
نویسندگان
چکیده
The first organocatalytic asymmetric synthesis of smyrindiol, by using an (S)-proline catalyzed enantioselective intramolecular aldol reaction as the key step, is described. Smyrindiol was synthesized from commercially available 2,4-dihydroxybenzaldehyde in 15 steps, with excellent stereoselectivity (de = 99%, ee = 99%). In the course of this total synthesis a new and mild coumarin assembly was developed.
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2012